About Me

I'm a fourth-year PhD student in the Tri-Institutional Program in Computational Biology & Medicine at Cornell, Memorial Sloan Kettering Cancer Center, and The Rockefeller University. I am advised by Quaid Morris and am an NSF Graduate Research Fellow. Previously, I was a research intern at Microsoft Research New England with Alex Lu and Kevin Yang.

Research

I work on representation learning for biological sequences. In particular, my past work has focused on foundation models for mRNA (Orthrus, mRNABench) and I am currently working on foundation models for DNA with MSR. My research leverages knowledge of evolutionary structure to design scalable pretraining objectives that are both sample efficient and highly predictive of downstream biological properties.

Selected Work

Orthrus: toward evolutionary and functional RNA foundation models

Philip Fradkin*, Ruian Shi*, Taykhoom Dalal*, Keren Isaev, Brendan J. Frey, Leo J. Lee, Quaid Morris, Bo Wang

Nature Methods, 2026

Orthrus leverages splice isoforms and orthology alongside contrastive learning to pretrain a state-of-the-art mRNA foundation model, which is broadly predctive of a wide range of mRNA properties and functions. It is extremely sample and parameter efficient, and can group mRNAs by function in its latent space, the first such demonstration (to our knowledge).

mRNABench: a curated benchmark for mature mRNA property and function prediction

Ruian Shi*, Taykhoom Dalal*, Philip Fradkin*, Divya Koyyalagunta, et al.

bioRxiv, 2025

mRNABench evaluates 75 nucleotide foundation models on 79 mature-mRNA prediction tasks, the only benchmark of its kind. We analyze results through the lens of parameter scaling, pretraining objectives, compressibility of genomic regions, and data splitting strategies.

PYPE: a pipeline for phenome-wide association and Mendelian randomization in investigator-driven biobank scale analysis

Taykhoom Dalal, Chirag J. Patel

Cell Patterns, 2024

PYPE runs phenome-wide association and Mendelian randomization analyses, annotates variants and genes, and generates standard plots from biobank-scale data.

* Equal contribution.

See Google Scholar or my CV for a complete list.

News

  • I'm interning at Microsoft Research New England with Alex Lu and Keving Yang!
  • Orthrus was published in Nature Methods.
  • We released mRNABench, a benchmark for mature mRNA property and function prediction.
  • PYPE was published in Cell Patterns.
  • I joined the Tri-Institutional PhD Program in Computational Biology & Medicine.
  • I received an NSF Graduate Research Fellowship!